Overcoming Anti-PEG Antibody Responses – a Novel PEOZ-lipid That Fails to Elicit an Immune Response to the Polymer-lipid in mRNA-LNP Formulations
Time: 9:30 am
day: Conference Day Two
Details:
- Overcoming toxicity challenges associated with PEG lipids by altering nanoparticle formulation and design employing a novel poly (2-ethyl-2-oxazoline) PEOZ-lipid
- Absence of an IgM or IgG response to PEOZ-lipid
- Substitution of PEG-lipid with PEOZ-lipid does not alter payload properties following in vitro and in vivo transfection
