Fireside Discussion: Overcoming Barriers in Repeat Dosing & Dose Escalation of LNP Therapeutics
Time: 4:00 pm
day: Conference Agenda
Details:
- Exploring how PEGylation impacts repeat dosing, including the development of anti-PEG antibodies, their effect on clearance and efficacy, and strategies to optimize PEG amount, chain length, and alternatives to minimize immune responses
- Discussing non-clinical and clinical biomarkers that inform on cumulative toxicity, highlighting translational markers that correlate with human outcomes and guide safety margins, dose selection, escalation decisions, and long-term monitoring
- Reviewing strategies to safely increase overall dose in LNP therapeutics by mitigating key toxicities, modifying LNP composition or administration routes, and applying real-time assessment of immunogenicity and inflammation to balance efficacy with immunotoxicity management
Speakers:
