Developing Computational Models With Predictive Capabilities for Ionizable Lipid Behavior in LNPs
Time: 11:25 am
day: Conference Agenda
Details:
- Leverage advanced molecular simulations to predict ionizable lipid pKa values and self-assembly behaviors across pH environments to better understand LNP formation and stability
- Uncover computational insights into pH-dependent mechanisms driving LNP toxicity and immunogenicity, informing safer and more effective formulation design
- Demonstrate how predictive modeling can accelerate next-generation LNP optimization, enabling data-driven design of novel ionizable lipid architectures
