Bridging the Translational Gap in Extrapolating LNP Safety & Immunogenicity in Preclinical Models
Time: 11:25 am
day: Conference Agenda
Details:
- Exploring how rodents, non-human primates, and humans differ in complement activation, cytokine responses, and anti-PEG antibody formation to determine immunogenicity
- Discussing the limitations of rodent and monkey data in forecasting human immunogenicity and toxicity, with examples from mRNA vaccines and therapeutic LNP studies
- Exploring strategies for dose scaling, biomarker selection, and aligning immune endpoints across species to improve predictive accuracy and reduce clinical surprises
Speakers:
