8:30am | Morning Registration & Coffee
9:20 am Chair’s Opening Remarks
Exploring the Effect of Composition of LNPs & Accurate Pre-Clinical Model Prediction Strategies
9:30 am Nanoparticle Single-Cell Multiomic Readouts Reveal That Cell Heterogeneity Influences LNP-Mediated mRNA Delivery
Synopsis
- Exploring high-throughput LNP screening
- Optimizing mRNA-based LNP delivery at single cell resolution
- Researching biodistribution and functional delivery of an mRNA-carrying LNP and identify immunogenic LNPs
10:00 am Roundtable: Evaluating Pre-Clinical In Vitro Models for Safety of LNPs
Synopsis
- Understanding the influencing factors of safety – lipids, modality
- Outlining performance and translatability of in vitro models
- Maximizing the potential of gene engineering and high-throughput methodologies
10:45 am Understanding of Immune Recognition of Nucleic Acids on Application Nanoparticles
Synopsis
- Different therapeutic nucleic acids (TNAs) can be organized in programmable nucleic acid nanoparticles (NANPs) for their simultaneous delivery to the diseased cells and further synchronized action
- Understanding immunological properties of TNAs and NANPs to expedite their clinical translation
- Delving into immunorecognition of NANPs defined by their architectural parameters that can be tuned to address specific therapeutic needs
VIRTUAL SESSION
11:15am | Morning Break & Speed Networking
12:00 pm Modifying Immunogenicity with a Multi-Cargo LNP System
Synopsis
- Discussing how additional functionalities (e.g., immune modulation) are enabled in a multi-cargo LNP system
- Reducing unwanted immune responses to LNP delivery systems
- Developing immune tolerizing LNPs for disease applications
12:30 pm Immunological Properties of LNPs & Nucleic Acid-Based APIs
Synopsis
- Exploring how the nanomaterial interacts with the immune system as an entity
- Reviewing the immunological compatibility of the carrier and API
- Understanding that the final formulation has unique properties that neither API or carrier have stand-alone
VIRTUAL SESSION
Measuring & Modulating Immunogenicity of LNP-Payload Composition
1:00pm | Networking Lunch
2:00 pm Translational Models to Evaluate LNP Immunogenicity & Reactogenicity
Synopsis
- Reviewing models currently used in the field and the value they bring in ranking lipids for immuno and reactogenicity
- Discussing new models that can be considered (e.g. MIMIC) and data supporting them
- Exploring challenges in model translatability
Spotlight Session
2:30 pm Understanding Immune Responses Linked to Physio-Chemical Characteristics of Non-Viral Delivery Systems
Synopsis
- Discussing the need for robust physio-chemical characterisation of delivery systems, to link to biological effect
- Evaluating the importance of route of administration for prioritizing immune assessment
- Requirement of more complex, physiologically relevant, models to assess immune responses
VIRTUAL SESSION
3:00pm | Afternoon Networking Break
3:30 pm Integrating Tolerability Assessments into Early LNP Discovery
4:00 pm Examining Immunological Profile of mRNA-LNP Therapeutics
Synopsis
- Determining interplay of immune responses with compositions and
characterization of LNP - Researching innate and adaptive immune systems of mRNA-LNP delivery
- Outlining mRNA-LNP delivery and immunogenicity
VIRTUAL SESSION
4:30 pm Complement Activation Related Pseudoallergy Associated with LNPs
Synopsis
- Delving into drivers of complement activation: size, shape, and charge of your LNP
- Understanding LNP interactions with complement proteins and subsequent activation of complement
- Identifying and preventing the impacts of complement activation